Misetionamide Pipeline

Our pipeline includes an active phase 1 dose escalation trial of misetionamide in combination with gemcitabine for pancreatic cancer, and a trial in ovarian cancer in combination with bevacizumab and PLD to initiate in 2025.

{{brizy_dc_image_alt imageSrc=

PROMISING PIPELINE

Broad applicability & potential.

Misetionamide, our lead asset, is a broadly active small molecule with a unique mechanism of action that inhibits two oncogenic transcription factors, c-MYC and NFκB. Acting through c-MYC, misetionamide selectively disrupts the energy metabolism of cancer cells leading to cancer cell death. Through NFκB inhibition, misetionamide inhibits cancer cells’ ability to proliferate and survive. ​

This powerful anti-cancer, dual-target mechanism of action makes misetionamide an attractive tumor cell selective agent across many cancers.​

{{brizy_dc_image_alt imageSrc=
{{brizy_dc_image_alt imageSrc=

PARTICIPATE

Become a clinical investigator or patient participant.

Are you a clinician or patient who is interested in learning about or participating in our active studies?

{{brizy_dc_image_alt imageSrc=

SCIENCE

Discover our novel mechanism of action.

Misetionamide’s mechanism of action inhibits two oncogenic transcription factors, c-MYC and NFκB.

{{brizy_dc_image_alt imageSrc=

+1.610.922.1910

Copyright © 2025 Panavance Therapeutics Inc.

Our Home

About

Resources

Participate


{{brizy_dc_image_alt imageSrc=

+1.610.922.1910

Copyright © 2025 Panavance Therapeutics Inc.

Our Home

About

Resources

Participate